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Five adults with mild sickle cell anemia share a β s chromosome with the same haplotype
Author(s) -
Bakioglu I.,
Hattori Y.,
Kutlar A.,
Mathew C.,
Huisman T. H. J.
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830200313
Subject(s) - haplotype , genetics , hemoglobinopathy , thalassemia , chromosome , disease , alpha (finance) , ineffective erythropoiesis , sickle cell anemia , karyotype , anemia , beta (programming language) , biology , medicine , cell , allele , gene , erythropoiesis , surgery , computer science , patient satisfaction , programming language , construct validity
Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (β s chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the β s # 31 chromosome promotes the synthesis of γ chains.