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A subpopulation of suppressor cells in Richter's syndrome with both monocytic and T‐lymphocytic characteristics
Author(s) -
Lahat N.,
Aghai E.,
Quitt M.,
Nir E.,
Froom P.
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830200312
Subject(s) - suppressor , cancer research , medicine , immunology , biology , cancer
We evaluated T‐lymphocyte functions in the peripheral blood of a patient with B‐cell chronic lymphocytic leukemia after transformation to large cell lymphoma (Richter's syndrome). A subpopulation of E‐rosette adherent cells were found with T‐lymphocytic surface markers (OKT3+/8+/4+), monocytic characteristics (latex ingestion, nonspecific esterase staining), and suppressor activity. In contrast to the patient's nonadherent T‐cells, this subpopulation suppressed PHA proliferation of autologous lymphocytes, pokeweed mitogen (PWM)‐induced proliferation of normal non‐T cells, and a mixed lymphocyte reaction. Further studies are warranted in patients with Richter's syndrome, in order to determine the frequency and significance of our findings.