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Dyskeratosis congenita with hypoplastic anemia: A stem cell defect
Author(s) -
Friedland M.,
Lutton J. D.,
Spitzer R.,
Levere R. D.
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830200112
Subject(s) - dyskeratosis congenita , medicine , anemia , dermatology , biology , genetics , dna , telomere
A case of dyskeratosis congenita (DC) with pancytopenia was studied in an attempt to elucidate the cause of the hypocellular bone marrow and pancytopenia. Levels of erythroid hemopoietic stem cells were estimated by clonal cell culture. Results showed a decrease in the number of precursor cells in both the bone marrow and the peripheral blood of this patient.