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Prolonged survival in Richter syndrome with subsequent reemergence of CLL: A case report including serial cell‐surface phenotypic analysis
Author(s) -
Baumann Michael A.,
Libnoch Joseph A.,
Patrick Catherine W.,
Choi Hongyung,
Keller Robert H.
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830200109
Subject(s) - clone (java method) , chronic lymphocytic leukemia , lymphoma , phenotype , medicine , somatic evolution in cancer , cell , oncology , immunology , leukemia , cancer research , biology , cancer , genetics , gene
The development of a large cell lymphoma in a patient with chronic lymphocytic leukemia (Richter syndrome) is associated with a poor prognosis. There is dispute regarding the clonal origin of the large cell component. We described a patient in whom prolonged remission of the large cell component was achieved with combination chemotherapy, followed by subsequent reemergence of the less aggressive CLL clone. Serial cell surface phenotypic data are presented suggesting origin of both histologies from a common B‐cell clone.