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Low dose cytosine arabinoside in acute myeloid leukemia: Remission is not due to differentiation induction
Author(s) -
Pinkerton Peter H.,
London Betty,
Cowan Donald H.
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830190412
Subject(s) - cytosine , myeloid leukemia , bone marrow , leukemia , complete remission , chromosome , cytarabine , medicine , complement (music) , cancer research , immunology , cytogenetics , myeloid , oncology , biology , dna , chemotherapy , genetics , gene , complementation , phenotype
A patient with acute nonlymphoblastic leukemia (FAB M4), showing a near tetraploid chromosome complement on his marrow cells, was treated with low dose cytosine arabinoside and achieved remission. During remission the near tetraploid marrow chromosome complement disappeared and reappeared upon relapse of leukemia. These findings are interpreted as evidence against differentiation induction in the leukemic cell line as a mechanism for remission of the disease in this patient.