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Immune hemolytic anemia following administration of antithymocyte globulin
Author(s) -
Prchal Josef T.,
Huang Shu T.,
Court Wayne S.,
Poon ManChiu
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830190112
Subject(s) - globulin , horse , medicine , antibody , immunology , coombs test , hemolytic anemia , anemia , immune system , biology , paleontology
Abstract Antithymocyte globulin is commonly used as a therapy for rejection of transplanted organs. Its use can be associated with many side effects. We report a significant hemolytic anemia following therapy with horse‐derived antithymocyte globulin. Several commercial Coombs' sera failed to yield a positive Coombs' test with the patient's erythrocytes; however, we were able to detect horse immunoglobulin on the patient's cells as well as on control red cells incubated with this particular preparation of antithymocyte globulin.