Immune hemolytic anemia following administration of antithymocyte globulin | Zendy

Prchal Josef T. | Zendy; Huang Shu T. | Zendy; Court Wayne S. | Zendy; Poon ManChiu | Zendy

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Immune hemolytic anemia following administration of antithymocyte globulin

Author(s) -

Prchal Josef T.,

Huang Shu T.,

Court Wayne S.,

Poon ManChiu

Publication year - 1985

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830190112

Subject(s) - globulin , horse , medicine , antibody , immunology , coombs test , hemolytic anemia , anemia , immune system , biology , paleontology

Antithymocyte globulin is commonly used as a therapy for rejection of transplanted organs. Its use can be associated with many side effects. We report a significant hemolytic anemia following therapy with horse‐derived antithymocyte globulin. Several commercial Coombs' sera failed to yield a positive Coombs' test with the patient's erythrocytes; however, we were able to detect horse immunoglobulin on the patient's cells as well as on control red cells incubated with this particular preparation of antithymocyte globulin.

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