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Multiple myeloma with crystalline inclusions in most hemopoietic cells
Author(s) -
Gabriel Laurence,
Escribano Luis,
Perales Jose,
Bellas Carmen,
Odriozola Jesus,
Navarro JoseLuis
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830180410
Subject(s) - immunoperoxidase , phagocytosis , haematopoiesis , clone (java method) , electron microscope , pathology , multiple myeloma , immunoglobulin light chain , antibody , chemistry , inclusion bodies , biology , microbiology and biotechnology , immunology , medicine , biochemistry , monoclonal antibody , stem cell , dna , physics , optics , escherichia coli , gene
Intracytoplasmic inclusions were observed at light and electron microscopy in the cells of most of the hemopoietic series, including erythroblasts, in a case of multiple myeloma IgG kappa. The inclusions were of crystalline nature, surrounded by smooth membrane. An indirect immunoperoxidase method on thick sections confirmed their immunoglobulin G kappa nature. The fact that crystals were observed in various hemopoietic series suggests that, except for the plasma cells, their presence is more likely due to phagocytosis than to synthesis and, therefore, that they are not a clone marker.