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High‐dose intravenous igg in the management of pregnancy in women with idiopathic thrombocytopenic purpura
Author(s) -
Besa Emmanuel C.,
Macnab Malcolm W.,
Solan Andrew J.,
Lapes Melvin J.,
Marfatia Usha
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830180406
Subject(s) - medicine , splenectomy , pregnancy , thrombocytopenic purpura , platelet , gestation , purpura (gastropod) , fetus , surgery , vaginal delivery , obstetrics , pediatrics , spleen , ecology , genetics , biology
Idiopathic thrombocytopenic purpura (ITP) may develop during pregnancy or affect later pregnancies, causing serious risks of bleeding to the mother and fetus. High‐dose intravenous immunoglobulin (IGIV) has caused an immediate and predictable rise in platelet count during the infusion in both adults and children with chronic or acute ITP. The rapid rise in platelet counts may be important in preparing pregnant women with ITP for surgery or delivery. We report our experience in managing two women at weeks 29 and 37 week of gestation who required splenectomy and/or cesarean section. Both patients demonstrated an increase in platelet counts, underwent surgery without excess bleeding, and had normal infants with normal platelets, and with mild thrombocytopenia at delivery.