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Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S‐C disease
Author(s) -
Sears David A.,
Udden Mark M.
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830180307
Subject(s) - splenic infarction , medicine , infarction , disease , hemoglobinopathy , splenic disease , spleen , splenectomy , pathology , myocardial infarction
Splenic atrophy or evidence of hyposplenism occurs in as many as one third of all patients with S‐C hemoglobinopathy. Yet there are few reports in the literature of clinically apparent splenic infarction in this disease. We describe four instances of acute splenic infarction in three patients with hemoglobin S‐C disease which illustrate a wide spectrum of clinical manifestations and severity. Of particular interest were the observations of coincident occurrences of splenic sequestration and functional hyposplenism with splenic infarction, suggesting a close pathophysiological relationship among these syndromes.