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Lymphoma of host origin in a marrow transplant recipient in remission of acute myeloid leukemia and receiving cyclosporin A
Author(s) -
Bloom Robert E.,
Brennan James K.,
Sullivan John L.,
Chiganti R. S. K.,
Dinsmore Robert,
O'Reilly Richard
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830180110
Subject(s) - lymphoma , myeloid leukemia , leukemia , bone marrow , medicine , transplantation , immunology , myeloid , virus , pathology
Lymphomas are an uncommon complication of solid organ transplantation and rarely occur after marrow transplantation. When post‐marrow transplant lymphomas have occurred, they have been of donor cell origin and when sought, Epstein‐Barr virus DNA has been found in the tumor. A 21‐year‐old woman developed a poorly differentiated lymphocytic lymphoma 6 months after bone marrow transplantation for acute myeloid leukemia in remission. Cyclosporin A had been used as an immunosuppressant. A chromosomal polymorphism demonstrated that the tumor was of host origin and contained a monoclonal tumor marker, 46, XX INV 4 (p16q12). The tumor did not contain the DNA of the Epstein‐Barr virus.