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Reproducibility of the French‐American‐British classification of acute Leukemia: The southwest oncology group experience
Author(s) -
Head David R.,
Savage Richard A.,
Cerezo Lizardo,
Craven Catherine M.,
Bickers John N.,
Hartsock Robert,
Hosty Thomas A.,
Saiki John H.,
Wilson Henry E.,
Morrison Francis S.,
Coltman Charles A.,
Hutton John J.
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830180108
Subject(s) - reproducibility , medicine , leukemia , myeloid leukemia , acute leukemia , oncology , pathology , chemistry , chromatography
After initial French‐American‐British (FAB) diagnosis by a multiinstitutional Southwest Oncology Group panel, slides of acute leukemia cases were recirculated to panel members for second review. The reproducibility of the FAB classification is analyzed. The classification is reproducible in the 70% range in panel reviewer hands and allows remarkable reproducibility in the morphologic and cytochemical distinction of acute lymphoid leukemia (ALL) from acute myeloid leukemia (AML). The limitations of a morphologic and cytochemical classification of acute leukemia are discussed. A simplification of the FAB system, merging M1, M2, and M4 as M7, is proposed; this simplification improves the system's reproducibility.