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Steroid‐induced hypersegmentation in neutrophiles
Author(s) -
Eichacker Peter,
Lawrence Christine
Publication year - 1985
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830180107
Subject(s) - glucocorticoid , granulocyte , medicine , neutrophile , absolute neutrophil count , gastroenterology , endocrinology , toxicity , neutropenia , inflammation
The effect of glucocorticoid administration on the nuclear segmentation of circulating granulocytes was studied in 13 patients with hematologic disorders and in two normal volunteers. In seventeen of eighteen courses, the granulocyte nuclear lobe count increased from 3.24 ± 0.12 (SD) to 3.41 ± 0.12 by the third day of treatment (P < .001). Nuclear segmentation increased even further with continued therapy during a week of observation. Thus, like deficiencies of folate and of vitamin B 12 , glucocorticoid therapy causes neutrophil hypersegmentation. The cause of this effect is not known.