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Chronic anemia progressing to auer rod‐positive and TdT‐positive acute leukemia with 5q– chromosomal anomaly
Author(s) -
Xavier Anita M.,
Kasimis Basil S.
Publication year - 1984
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830170411
Subject(s) - medicine , bone marrow , terminal deoxynucleotidyl transferase , pathology , acute leukemia , anemia , leukemia , sideroblastic anemia , immunohistochemistry , tunel assay
The 5q– syndrome is a recently described entity characterized by partial deletion of the long arm of chromosome No. 5 and by hematologic findings of chronic anemia with reticulocytopenia, nonlobulated megakaryocytes, and megathrombocytes. We report on a patient with the hematologic features of the 5q– syndrome who progressed to acute leukemia and whose uniqueness consisted of 1) lack of additional cytogenetic abnormalities, 2) presence of blasts with Auer rods, and 3) bone marrow cells positive for terminal deoxynucleotidyl transferase. His leukemia was refractory to conventional chemotherapy.