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Variations in the hereditary patterns of factor VIII complex in a large kindred: Coexistence of hemophilia a with von willebrand
Author(s) -
Tavori S.,
Tatarsky I.
Publication year - 1984
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830170102
Subject(s) - von willebrand factor , von willebrand disease , coagulation , medicine , genetics , immunology , biology , platelet
Coagulation studies and clinical observations were carried out in 47 members belonging to three generations in one kindred. Classical Hemophilia A, Von Willebrand (VWD) variants, and normal individuals were revealed in this study. The coexistence of Hemophilia A and VWD in different siblings of the same progenitors indicates the difficulty to distinguish between these two major factor VIII abnormalities as two different traits. A hypothesis based on these findings is elaborated.