Premium
“Leukemic” pattern of in vitro growth in a patient with Down syndrome and transient myeloproliferative disorder
Author(s) -
Mendelow Barry,
Krawitz Selma,
Cohn Richard,
Bernstein Renée
Publication year - 1984
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830160311
Subject(s) - transient (computer programming) , in vitro , medicine , myeloproliferative disorders , genetics , biology , computer science , operating system
Abstract Peripheral blood cells from a female infant with Down syndrome and over 60% circulating myeloblasts were cultured in soft agar. Growth was virtually restricted to cluster formation, and cluster‐forming cells resided almost exclusively in the very light density fraction (SG < 1.062). Morphological assessment of clusters revealed no evidence of cellular differentiation beyond the blast cell stage. Despite receiving no specific chemotherapy, the peripheral blood normalized within 2 months, and there was no evidence of leukemia when the patient died aged 1 year from cardiac pathology. The findings indicate that caution should be exercised when assessing prognosis on the basis of in vitro growth characteristics in such patients.