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Procainamide‐induced thrombocytopenia
Author(s) -
Rosenstein Robert,
Kosfeld Rodney E.,
Leight Leonard,
Liu Yong K.
Publication year - 1984
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830160210
Subject(s) - procainamide , leukopenia , discontinuation , medicine , prednisone , platelet , gastroenterology , anemia , chemotherapy
An 81‐year‐old female developed marked thrombocytopenia associated with numerous megakaryocytes in the bone marrow, but without anemia or leukopenia, after taking procainamide (3 g/day) for a period of 2 months. Despite continuation of this medication, treatment with prednisone led to rapid rise in platelet count, and withdrawal of steroid was followed by prompt recurrence of thrombocytopenia. The platelet counts returned to normal after discontinuation of procainamide, and read‐ministration of this drug was followed by reappearance of thrombocytopenia. These observations indicate that exposure to procainamide can cause isolated thrombocytopenia, probably due to immune‐mediated destruction of platelets, and that treatment with prednisone may be promptly beneficial in patients with procainamide‐induced severe thrombocytopenia and bleeding.