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Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam
Author(s) -
Nalbandian Robert M.,
Henry Raymond L.,
Burek C. Lynne,
Diglio Clement A.,
Goldman Arnold I.,
Taylor Gregory W.,
Hoffman William H.
Publication year - 1983
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830150206
Subject(s) - piracetam , endothelium , medicine , hemoglobinopathy , pharmacology , hemolytic anemia
Abstract Erythrocytes from both normal and sickle cell donors were incubated on a bed of cultured rat vascular endothelial cells. Although the adherence of the erythrocytes to the endothelial cells was equivalent for both classes of donor, addition of 1.5 mM piracetam significantly decreased this adherence regardless of donor.