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Autoimmune thrombocytopenic purpura. Comparison of three different methods for the detection of platelet antibodies
Author(s) -
Vizcaíno Gilberto J.,
DiezEwald María
Publication year - 1983
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830140309
Subject(s) - platelet , medicine , antibody , thrombocytopenic purpura , immunoperoxidase , immunology , persistence (discontinuity) , purpura (gastropod) , gastroenterology , biology , monoclonal antibody , geotechnical engineering , engineering , ecology
An evaluation of three techniques for detection of antiplatelet antibodies in ATP is made. The platelet factor 3 availability after immunoinjury and the immunohystochemical technique using immunoperoxidase were more sensitive than 14 C‐5HT release from platelets for this purpose. The percentage of positive cases was similar in acute and chronic ATP patients while it significantly fell in cases in remission. A high proportion of patients in clinical remission had normal platelet aggregation, despite the persistence of antiplatelet antibodies.