Essential thrombocythemia: A clonal disorder of hematopoietic stem cell | Zendy

Singal Usha | Zendy; Prasad Ananda S. | Zendy; Halton David M. | Zendy; Bishop Carter | Zendy

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Essential thrombocythemia: A clonal disorder of hematopoietic stem cell

Author(s) -

Singal Usha,

Prasad Ananda S.,

Halton David M.,

Bishop Carter

Publication year - 1983

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830140212

Subject(s) - essential thrombocythemia , haematopoiesis , stem cell , hematopoietic stem cell , biology , isozyme , platelet , multipotent stem cell , phosphogluconate dehydrogenase , myeloproliferative disorders , cancer research , immunology , dehydrogenase , glucose 6 phosphate dehydrogenase , enzyme , genetics , biochemistry , progenitor cell

We studied 5 patients with essential thrombocythemia utilizing glucose‐6‐phosphate dehydrogenase (G‐6‐PD) enzyme as a cell marker for determining clonality. One of the patients was found to be heterozygous for isoenzymes B and A in the nonhaemopoietic tissues such as fibroblasts, but manifested only isoenzyme type B in the erythrocytes, neutrophils, and platelets. Our studies support the concept that essential thrombocythemia is a clonal disorder arising in a multipotent stem cell.

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