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Essential thrombocythemia: A clonal disorder of hematopoietic stem cell
Author(s) -
Singal Usha,
Prasad Ananda S.,
Halton David M.,
Bishop Carter
Publication year - 1983
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830140212
Subject(s) - essential thrombocythemia , haematopoiesis , stem cell , hematopoietic stem cell , biology , isozyme , platelet , multipotent stem cell , phosphogluconate dehydrogenase , myeloproliferative disorders , cancer research , immunology , dehydrogenase , glucose 6 phosphate dehydrogenase , enzyme , genetics , biochemistry , progenitor cell
We studied 5 patients with essential thrombocythemia utilizing glucose‐6‐phosphate dehydrogenase (G‐6‐PD) enzyme as a cell marker for determining clonality. One of the patients was found to be heterozygous for isoenzymes B and A in the nonhaemopoietic tissues such as fibroblasts, but manifested only isoenzyme type B in the erythrocytes, neutrophils, and platelets. Our studies support the concept that essential thrombocythemia is a clonal disorder arising in a multipotent stem cell.