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A family of hereditary stomatocytosis associated with normal level of Na + ‐K + ‐ATPase activity of red blood cells
Author(s) -
Mutoh Shigeaki,
Sasaki Ryuhei,
Takaku Fumimaro,
Aoyama Masako,
Moriyama Shinichi,
Yoshimoto Masahiro,
Yawata Yoshihito
Publication year - 1983
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830140203
Subject(s) - erythrocyte fragility , hemolytic anemia , sodium , splenectomy , atpase , potassium , medicine , red blood cell , hereditary spherocytosis , anemia , chemistry , endocrinology , hemolysis , microbiology and biotechnology , biochemistry , biology , enzyme , spleen , organic chemistry
A rare familial case of hereditary stomatocytosis with hemolytic anemia, increased auto‐hemolysis, increased osmotic fragility, and shortened erythrocyte survival is described. The erythrocytes were abnormally permeable to sodium and potassium. In addition, “Na‐K pump” rate of the red blood cells was increased, while Na + ‐K − ‐ATPase, Mg 2+ ‐ATPase and Mg 2+ ‐Ca 2+ ‐ATPase activities were within normal limits. Splenectomy induced marked improvement of anemia.