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Febrile Transfusion Reaction Following Initial Transfusion in a Man With Immunoblastic Lymphadenopathy and Granulocyte Autoantibodies
Author(s) -
Barnes Harry M.,
Poon ManChiu,
Huang Shu Tsong,
Conrad Marcel E.,
Lin John,
McGowan Eoline I.
Publication year - 1983
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830140112
Subject(s) - granulocyte , medicine , immunology , autoantibody , platelet , antibody , blood transfusion , immunofluorescence , packed red blood cells
A 69‐year‐old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, but not when freeze‐thawed red blood cells were used. Immunofluorescence techniques demonstrated granulocyte antibodies in his serum and on the surface of his granulocytes. Circulating immune complex, HLA, and platelet antibodies were not present. The granulocyte antibodies fluctuated in titers with disease activities, and could be completely removed from the serum by autologous granulocyte absorption. We conclude that our patient had granulocyte autoantibodies which probably produced febrile transfusion reactions.