Premium
Paroxysmal nocturnal hemoglobinuria terminating in TdT‐positive acute leukemia
Author(s) -
Katahira Jun'Ichi,
Aoyama Masako,
Oshimi Kazuo,
Mizoguchi Hideaki,
Okada Michiko
Publication year - 1983
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830140110
Subject(s) - paroxysmal nocturnal hemoglobinuria , terminal deoxynucleotidyl transferase , leukemia , immunology , myeloid , medicine , immunofluorescence , pathology , biology , antibody , tunel assay , immunohistochemistry
A case of paroxysmal nocturnal hemoglobinuria (PNH) which developed terminal transfer‐ase (TdT)‐positive leukemia 5 years after the diagnosis of PNH was studied. Most of the leu‐kemic cells were suggestively lymphoid by cytochemistry and electron microscopy, and TdT‐positive by immunofluorescence studies. The development of acute lymphoblastic leukemia during the course of PNH suggests that in PNH the clonal abnormality may involve lymphoid cells as well as myeloid cells, thus raising the possibility of the disease being a disorder of the pluripotential stem cell.