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Successful treatment of thrombotic thrombocytopenia purpura by vincristine
Author(s) -
Schreeder Marshall T.,
Prchal Josef T.
Publication year - 1983
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830140109
Subject(s) - vincristine , medicine , purpura (gastropod) , thrombotic thrombocytopenic purpura , platelet , immunology , chemotherapy , cyclophosphamide , ecology , biology
Two patients with thrombotic thrombocytopenia purpura (TTP) are described in whom vincristine administration appeared to play a role in successful outcomes. The first patient with chronic TTP responded partially to plasma exchange followed by plasma infusion and transiently to splenectomy, but developed a complete long lasting remission after a single injection of intravenous vincristine. The second patient developed a complete remission following vincristine administration and plasma exchange. Although vincristine's mechanism of action in TTP is obscure, we suggest that vincristine is effective in the treatment of this infrequent and often fatal disease.