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Sideroblastic anemia terminating in myelofibrosis
Author(s) -
Lukowicz Daniel F.,
Myers Thomas J.,
Grasso Joseph A.,
Albala Maurice M.
Publication year - 1982
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830130309
Subject(s) - myelofibrosis , medicine , sideroblastic anemia , myeloid , metaplasia , extramedullary hematopoiesis , anemia , splenectomy , bone marrow , pathology , gastroenterology , haematopoiesis , spleen , stem cell , biology , genetics
Two patients with primary acquired sideroblastic anemia who eventually developed myelofibrosis with myeloid metaplasia are reported. Splenectomy was performed in one patient because of increasing blood transfusion requirements, and splenic histology revealed both myeloid metaplasia and ringed sideroblasts. The second patient showed a partial response of the sideroblastic anemia to pyridoxine therapy during the early stages of development of the myelofibrosis. Myelofibrosis with myeloid metaplasia may represent a nonspecific response of the marrow tissue to sideroblastic anemia as to other primary hematologic disorders.