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The role of autologous helper and suppressor T cells in the regulation of human granulopoiesis
Author(s) -
Barr Ronald D.,
Stevens Catherine A.
Publication year - 1982
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830120403
Subject(s) - granulopoiesis , biology , immune system , suppressor , immunology , microbiology and biotechnology , in vitro , t cell , progenitor cell , t lymphocyte , null cell , stem cell , cell culture , biochemistry , genetics , gene
Helper and suppressor T cells play a physiological role in immunoregulation and possibly in other biological systems. Previous studies have suggested that unfractionated T cells influence human blood cell formation in vitro. Subpopulations of such cells (T M and T G cells) were prepared by immune ox erythrocyte resetting techniques. Co‐cultures were established in semi‐solid agar with autologous null lymphocytes as a source of granulocyte—macrophage progenitor cells (CFU‐GM). T M (helper) cells produced an increase and T G (suppressor) cells a decrease in the expression of CFU‐GM as reflected in the number of GM colonies generated by comparison with cultures of null lymphocytes alone. These data point to a contribution from T lymphocyte subpopulations to the physiological regulation of human granulopoiesis.