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A rapid quantitation of platelet‐associated igg by nephelometry
Author(s) -
Morse Bernard S.,
Giuliani Dennis,
Nussbaum Murray
Publication year - 1982
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830120309
Subject(s) - platelet , medicine , nephelometry , thrombocytopenic purpura , immune thrombocytopenia , immunology , purpura (gastropod) , gastroenterology , multiple myeloma , antibody , ecology , biology
Platelet‐associated IgG (PAIgG) was measured by a simple rapid nephelometric technique using washed solubilized platelets and commercially available, prestandardized reagents. Normal subjects with normal platelet counts had PAIgG levels of 2.1–6.7 fg/platelet. Subjects with idiopathic immune thrombocytopenic purpura (ITP) had levels of 7.2–43.3 fg/platelet. Ninety percent of ITP patients had values exceeding 2 SD units of the mean of normal subjects. Elevated values were also found in 17% of patients with recovered ITP, patients with SLE with and without thrombocytopenia, patients with thrombocytopenia occurring during septicemia, and patients with IgG myeloma. Results can be obtained within several hours of receipt of blood specimen, and are similar to the reports that used more complex techniques.