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Agranulocytosis associated with chronic oral administration of cloxacillin for suppression of staphylococcal osteomyelitis
Author(s) -
Shah I.,
Kumar K. S.,
Lerner A. M.
Publication year - 1982
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830120213
Subject(s) - cloxacillin , medicine , rash , osteomyelitis , penicillin , staphylococcal infections , eosinophilia , antibiotics , oral administration , staphylococcus aureus , immunology , gastroenterology , microbiology and biotechnology , genetics , bacteria , biology
Oral cloxacillin was used for chronic suppression of a 59‐year‐old woman with staphylococcal osteomyelitis. She received 380.5 gm of cloxacillin over 263 consecutive days. Severe agranulocytosis followed, reverting rapidly to normal with cessation of drug. The absence of signs of an allergic reaction such as rash, fever, or eosinophilia suggests that cloxacillin, like other semisynthetic penicillins, may exert a direct bone marrow toxicity.