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Acute monocytic leukemia: A surface marker study
Author(s) -
Mirchandani Ila,
Tabaczka Pamela,
Palutke Margarita
Publication year - 1982
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830120206
Subject(s) - surface immunoglobulin , antibody , acute monocytic leukemia , receptor , leukemia , immunology , complement receptor , antiserum , monocyte , monocytic leukemia , antigen , biology , complement system , b cell , biochemistry
Abstract Thirteen cases of acute monocytic leukemia (AMoL) were studied morphologically, cytochemically, and immunologically in an attempt to determine similarities and/or differences between acute monocytic and lymphocytic leukemias. Single class surface immunoglobulins (IgG kappa) were seen in six cases. These markers are thought to represent serum immunoglobulins attached to the leukemic monocytes via the receptors for the Fc portion of immunoglobulin and are not synthesized by the cells as is the case with B lymphocytes. Receptors for complement were also noted. It appears that surface immunoglobulins and receptors for the Fc portion of the immunoglobulin and complement, which are found on several classes of normal lymphocytes and monocytes, may also be found on leukemic monocytes. Antisera to B lymphocytes, detecting HLA‐DRw antigens, also reacted with some of the leukemic monocytes.