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Human leukocyte interferon‐mediated granulopoietic differentiation arrest and its abrogation by lithium carbonate
Author(s) -
Verma Dharmvir S.,
Spitzer Gary,
Gutterman Jordan U.,
Beran Miloslav,
Zander Axel R.,
McCredie Kenneth B.
Publication year - 1982
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830120106
Subject(s) - granulocyte , progenitor cell , interferon , immunology , lithium carbonate , lithium (medication) , haematopoiesis , cancer research , chemistry , biology , microbiology and biotechnology , stem cell , endocrinology , ion , organic chemistry , ionic bonding
Interferon has been shown to inhibit erythropoietic and granulopoietic differentiation. Since lithium carbonate (Li) elevates granulocyte levels in a variety of neutropenic disorders, we investigated the effect of Li on human leukocyte interferon (HLIF)‐mediated inhibition of granulopoietic differentiation. Using an agar culture technique for cloning granulocyte‐macrophage progenitor cells (GM‐CFC), we demonstrated that Li blocks HLIF‐induced granulopoietic differentiation arrest in a dose‐dependent manner. Results of removal of T lymphocytes from marrow cells suggest that this Li effect is not mediated through marrow T lymphocytes.