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A neutrophil lysozyme leak in patients with familial mediterranean fever
Author(s) -
BarEli Menashe,
Territo Mary C.,
Peters Robert S.,
Schwabe Arthur D.
Publication year - 1981
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830110407
Subject(s) - familial mediterranean fever , lysozyme , lactoferrin , colchicine , pathogenesis , immunology , granulocyte , medicine , enzyme , acid phosphatase , chemistry , biochemistry , disease
Polymorphonuclear cells derived from the peripheral blood of patients with Familial Mediterranean Fever release more lysozyme in response to high temperatures (42°, 46°C) than do control cells. No differences between the FMF and control cells were observed in the release of acid phosphatase, β‐glucuronidase, or lactoferrin. Colchicine treatment had no effect on the measurable release of the enzyme from PMNs derived from FMF patients. The increased release of lysozyme in response to high temperatures appears to be specific to FMF neutrophils, and was not found in PMNs from non‐FMF patients with febrile or inflammatory diseases, nor was it seen in monocytes derived from the FMF patients. It is suggested that the increased release of lysozyme from the neutrophils may be of importance in the pathogenesis of FMF.