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Complement‐fixing platelet autoantibodies in autoimmune thrombocytopenia
Author(s) -
Kayser W.,
MuellerEckhardt C.,
Budde U.,
Schmidt R. E.
Publication year - 1981
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830110213
Subject(s) - autoantibody , autoimmune hemolytic anemia , autoimmune thrombocytopenia , immunology , medicine , complement fixation test , platelet , antibody , autoimmune disease , evans syndrome , autoimmunity , complement system , immune thrombocytopenia , serology
A 16‐year‐old male patient is described with chronic autoimmune thrombo‐cytopenic purpura and, after two years, “warm” autoimmune hemolytic anemia (Evans syndrome) who transiently developed complement‐fixing platelet autoantibodies. The autoreactivity of these antibodies was established by quantitative complement fixation as well as by absorption and elution studies using autologous platelets. We believe this to be the first documented case with this very rare and peculiar type of platelet autoantibody.