Premium
Standardization of platelet function tests
Author(s) -
RoperDrewinko Pamela R.,
Drewinko Benjamin,
Corrigan Gail,
Johnston Dennis,
McCredie Kenneth B.,
Freireich Emil J.
Publication year - 1981
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830110210
Subject(s) - platelet , reproducibility , mean platelet volume , medicine , standardization , population , blood platelet disorders , function (biology) , platelet aggregation , biology , statistics , mathematics , computer science , environmental health , operating system , evolutionary biology
Abstract Methods for the standardization of several currently used platelet function tests (bleeding time, capillary fragility, platelet retention, platelet aggregation, platelet factor 3, and platelet volume profiles) are presented. Different variables that may interfere with the reproducibility of the results of each assay were identified and standardized. Using the standardized techniques, the range of normal values for each test was determined in a large population of normal volunteers and used to identify disease states by comparing patient results with those of the normal population. A format for presenting the entire profile of platelet function parameters is proposed.