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The aggregation of human platelets by ascitic fluid: A possible mechanism for disseminated intravascular coagulation complicating LeVeen shunts
Author(s) -
Salem Hatem H.,
Koutts Jerry,
Handley Chris,
Van Der Weyden Martin B.,
Dudley Frank J.,
Firkin Barry G.
Publication year - 1981
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830110206
Subject(s) - disseminated intravascular coagulation , platelet , medicine , coagulation , ascitic fluid , aspirin , pathology , immunology , gastroenterology , ascites
To identifiy causative factors responsible for the disseminated intravascular coagulation complicating peritoneovenous (LeVeen) shunts, the ascitic fluid from 12 patients with alcoholic liver disease or peritoneal malignancy was examined for its effects on human platelets. In all patients, concentrated ascitic fluid caused irreversible platelet aggregation. Properties of the aggregating factor suggested that it is collagen, and subsequently, the presence of collagen in ascitic fluid was confirmed. This finding, together with the known effects of collagen on platelets and contact clotting factors, would be sufficient to explain the development of disseminated intravascular coagulation following this procedure. Aspirin by inhibiting collagen‐induced aggregation may have a therapeutic role in the management of this problem.