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Immune complexes in hemophilia
Author(s) -
Poskitt Thomas R.,
Poskitt Paula K. F.,
Bean Cheryl A.,
Arkel Yale S.
Publication year - 1981
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830110205
Subject(s) - medicine , immunology , antibody , immune system , von willebrand factor , coagulopathy , disease , factor ix , immunoassay , von willebrand disease , gastroenterology , platelet
Circulating immune complexes (ICs), assayed by the L1210 enzyme‐linked immunoassay, were detected in 48% of patients with hemophilia A, 50% of patients with von Willebrand's disease, and in none of our patients with hemophilia B. Eighty‐five % of the hemophilia A and B patients had mild to moderate disease with only one patient demonstrating a circulating inhibitor. No correlation was found between IC levels and hepatitis B infection, SGOT, disease severity, total quantity of factor VIII or IX infused, time interval from last infusion, or rheumatoid factor positivity. Although the nature of the ICs is not known, the similarity of IC levels between hemophilia A and von‐Willebrand's disease is discussed with regard to antibodies generated to non‐procoagulant portions of the factor VIII molecule.