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Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood
Author(s) -
Humphrey M. J.,
Hutter J. J.,
Tom W. W.
Publication year - 1981
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830110113
Subject(s) - hypereosinophilia , eosinophilia , monosomy , pathology , myeloproliferative disorders , bone marrow , medicine , etiology , population , immunology , karyotype , biology , genetics , chromosome , environmental health , gene
Hyperosinophilia in association with a monosomy 7 myeloproliferative disorder is described in an eight‐year‐old boy. Antileukemic treatment resulted in a decrease in the eosinophilia, but did not appear to affect the blast cell population or the presence of monosomy 7 cells in the bone marrow. These findings suggest that bone marrow karyotyping may be useful in differentiating pre‐malignant causes of eosinophilia from those with a more benign etiology.