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Antigranulocyte antibodies and deranged immune function associated with phenytoin‐induced serum sickness
Author(s) -
Menitove Jay E.,
Rassiga Anne L.,
McLaren Gordon D.,
Daniel Thomas M.,
Mahmoud Adel A. F.
Publication year - 1981
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830100307
Subject(s) - phenytoin , immunology , pokeweed mitogen , medicine , serum sickness , antibody , immune system , lymphocyte , immunity , pharmacology , in vitro , peripheral blood mononuclear cell , biology , epilepsy , biochemistry , psychiatry
Abstract A phenytoin‐associated serum‐sickness‐like syndrome was followed by severe pancytopenia in a 17‐year‐old female. Serum obtained during the acute phase of her illness contained antibodies against homologous eosinophils and neutrophils, antibodies against autologous neutrophils, and antibodies to phenytoin. The serum also inhibited bone marrow granulocyte colony formation in vitro. Lymphocyte transformation by pokeweed mitogen was impaired and, after recovery, the patient's lymphocytes were transformed in vitro by the addition of phenytoin. These data demonstrate that profound derangements of immunity can be associated with a phenytoin‐induced serum‐sickness‐like illness.