A defect in the formation of uropod‐bearing lymphocytes (hand‐mirror cells) in patients with the wiskott‐aldrich syndrome | Zendy

McGraw Thomas P. | Zendy; Folds James D. | Zendy; Whisnant John K. | Zendy; Phillips Terry M. | Zendy; Stass Sanford A. | Zendy

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A defect in the formation of uropod‐bearing lymphocytes (hand‐mirror cells) in patients with the wiskott‐aldrich syndrome

Author(s) -

McGraw Thomas P.,

Folds James D.,

Whisnant John K.,

Phillips Terry M.,

Stass Sanford A.

Publication year - 1981

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830100207

Subject(s) - immune system , wiskott–aldrich syndrome , wiskott–aldrich syndrome protein , immunology , motility , microbiology and biotechnology , biology , leukemia , lymphocyte , cell , cytoskeleton , genetics , actin cytoskeleton , gene

The formation of a uropod by lymphocytes (hand‐mirror cells) represents a morphologic stage of immune activation and motility in lymphocytes. Immune complexes have been previously shown to induce hand‐mirror‐cell (HMC) formation in human lymphocytes and have been associated with increased number of HMC in acute leukemia. We studied the ability of immune complexes to induce HMC in patients with Wiskott‐Aldrich syndrome (WAS), a disease of cellular immune deficiency. Our findings indicate that lymphocytes from patients with WAS adhere to immune complexes but have a defect in their ability to form HMC when compared with normal human lymphocytes. These results support the concept that immune complexes induce HMC formation and that the HMC is related to the normal cellular immune response.

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