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Pituitary‐adrenal axis function in sickle cell anemia and its relationship to leukocyte alkaline phosphatase
Author(s) -
Rosenbloom Barry E.,
Odell William D.,
Tanaka Kouichi R.
Publication year - 1980
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830090404
Subject(s) - endocrinology , medicine , alkaline phosphatase , metyrapone , hypoglycemia , sickle cell anemia , hormone , adrenal insufficiency , hydrocortisone , adrenocorticotropic hormone , disease , chemistry , insulin , enzyme , biochemistry
The function of the pituitary‐adrenal axis and leukocyte alkaline phosphatase activity were evaluated in eight patients with sickle cell disease during a painful crisis and when crisis‐free. The leukocyte alkaline phosphatase (LAP) score did not increase during crisis; the scores were in the low‐normal range during crisis and noncrisis periods. Insulin‐induced hypoglycemia produced normal growth hormone responses during both crisis and crisis‐free periods. Plasma cortisol concentrations were diminished in the crisis group. Also impaired was 11‐deoxycortisol production in both groups after metyrapone. These findings indicate that a mild defect in the hypothalamic‐pituitary‐adrenal axis exists in sickle cell disease patients.