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Post‐transfusion purpura: An enigma of alloimmunization
Author(s) -
Lau Peter,
Sholtis Carol M.,
Aster Richard H.
Publication year - 1980
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830090312
Subject(s) - medicine , immunofluorescence , platelet , purpura (gastropod) , antibody , immunology , titer , blood transfusion , transfusion therapy , pathogenesis , indirect immunofluorescence , biology , ecology
A patient with post‐transfusion purpura is reported. This female patient, sensitized by previous blood transfusion, developed symptomatic thrombocytopenia seven days after a second blood transfusion. A platelet antibody, which had anti‐P1 A1 specificity, was identified by 51 Cr‐release assay and by indirect immunofluorescence. Hemorrhage stopped abruptly after plasma exchange therapy. Thrombocytopenia did not recur when the patient was further challenged with P1 A1 ‐positive blood and plasma. Anti‐P1 A1 antibody, detectable by immunofluorescence but not by complement‐dependent platelet cytoxicity, persisted in high titer for at least one year after recovery. The heterogeneity and pathogenesis of this clinical syndrome are discussed.