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Von willebrand factor (VIII VWF ) in lyophilized factor VIII concentrates
Author(s) -
McCue Miles J.,
Brossoit Arthur D.,
Marmer Daniel J.,
Head David R.
Publication year - 1980
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830090105
Subject(s) - von willebrand factor , von willebrand disease , medicine , chemistry , immunology , platelet
Several (14) commercially prepared, lyophilized Factor VIII concentrates were assayed for VIII AHF , VIII Ag , and VIII VWF . Significant levels of VIII Ag (immunologic) and VIII VWF (von Willebrand Factor) were present in addition to VIII AHF (Functional VIII, Antihemophilic Factor, Factor VIII coagulant activity). An average of 0.95 units of VIII VWF (range 0.47–1.7) were present for every 1.0 unit of VIII AHF (as stated on the manufacturer's label). We suggest that the various lyophilized preparations of Factor VIII concentrate available could be assayed for VIII VWF and should be tested therapeutically in patients with von Willebrand disease.