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Acceleration of F‐cell production in response to experimentally induced anemia in adult baboons (Papio cynocephalus)
Author(s) -
Nute Peter E.,
Papayannopoulou Th.,
Chen P.,
Stamatoyannopoulos G.
Publication year - 1980
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830080205
Subject(s) - hematocrit , anemia , hemoglobin , phlebotomy , endocrinology , medicine , biology , fetal hemoglobin , fetus , red cell , in vivo , erythropoiesis , physiology , pregnancy , genetics , microbiology and biotechnology
Changes in levels of fetal hemoglobin and Hb F‐containing erythrocytes (F‐cells) were monitored in adult baboons (Papio cynocephalus) rendered acutely anemic by phenylhydrazine or phlebotomy, or chronically anemic by a combination of both forms of treatment. The highest levels of Hb F were observed in acutely anemic animals from 21 to 29 days after initiation of treatment and represented 2.2‐ to 5.6‐fold increases over levels measured prior to induction of anemia. Changes in F‐cell levels correlated well with changes in proportions of Hb F (r = 0.89), and peak F‐cell levels exceeded initial levels by factors ranging from 6 to 11.7. These data confirm previous findings and indicate that adult baboons respond to severe anemic stress by producing increased numbers of Hb F‐containing cells. Thus, P cynocephalus appears to be a suitable model for the study, in vivo, of Hb F regulation in man, since it is likely that changes in Hb F production are mediated by similar mechanisms in both species.