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Effect of zinc on hyperammonemia in sickle cell anemia subjects
Author(s) -
Prasad Ananda S.,
Rabbani Parviz,
Warth James A.
Publication year - 1979
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830070404
Subject(s) - hyperammonemia , zinc , sickle cell anemia , anemia , medicine , zinc deficiency (plant disorder) , hemoglobin , endocrinology , chemistry , disease , organic chemistry
An increase in plasma ammonia level in human volunteers on restricted zinc intake, and in zinc‐deficient rats, has recently been reported. Inasmuch as zinc deficiency has been observed in sickle cell anemia patients, we measured plasma ammonia levels in such subjects. In this report we document hyperammonemia in sickle cell anemia patients that was corrected with zinc therapy.