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Mechanisms of thrombocytopenia in varicella
Author(s) -
Feusner James H.,
Slichter Sherrill J.,
Harker Laurence A.
Publication year - 1979
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830070308
Subject(s) - platelet , fibrinogen , medicine , megakaryocyte , antibody , immunology , immune thrombocytopenia , immune system , mean platelet volume , hematology , gastroenterology , biology , haematopoiesis , stem cell , genetics
51 Cr‐labeled platelet and 125 I‐labeled fibrinogen kinetic studies in four thrombocytopenic children with varicella infection revealed marked platelet destruction (platelet survival times 0.1, 0.4, 1.0, and 2.4 days) and relatively normal fibrinogen disappearance. The platelet count was directly related to the platelet survival time. Marrow megakaryocyte mass was increased twofold to fourfold. IgG or IgM antiplatelet antibody was present on autologous platelets in the three patients tested. These data suggest that thrombocytopenia in some patients with varicella is the consequence of immune mediated platelet destruction.