Premium
Cold agglutinin autoimmune hemolytic anemia in nonhematologic malignancies
Author(s) -
Wortman J.,
Rosse W.,
Logue G.
Publication year - 1979
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830060312
Subject(s) - cold agglutinin , autoimmune hemolytic anemia , cold agglutinin disease , medicine , antibody , hemolytic anemia , immunology , titer , anemia , coombs test , immunoglobulin m , immunoglobulin g
Four patients with nonhematologic malignancies had the simultaneous finding of hemolytic anemia due to high‐titer cold agglutinins. In each patient, the cold agglutinin had “anti‐I” specificity and was of the IgM kappa immunoglobulin class. Although patients with hematologic malignancies not uncommonly have cold agglutinins, the association between these antibodies and nonhematologic malignancies is unusual.