Premium
Acute leukemia and preleukemia in eight males in a family: An X‐linked disorder?
Author(s) -
Li Frederick P.,
Marchetto David J.,
Vawter Gordon F.
Publication year - 1979
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830060109
Subject(s) - preleukemia , wife , leukemia , acute leukemia , disease , medicine , inheritance (genetic algorithm) , immunology , genetics , biology , gene , political science , law
Eight males in a family died of acute leukemia or a potentially preleukemic blood disease. Three patients were descendants of a man through his first wife, and the other five through his second wife. The pattern of disease in the family suggests X‐linked inheritance through the two wives, although other mechanisms cannot be excluded. No detectable action of environmental leukemogens was observed in this family disorder.