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Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia
Author(s) -
LieInjo Luan Eng,
Randhawa Z. I.,
Kane J. P.,
Ganesan J.,
George R.
Publication year - 1979
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830060104
Subject(s) - hydrops fetalis , thalassemia , medicine , hemoglobinopathy , alpha thalassemia , isoleucine , pediatrics , gastroenterology , hemolytic anemia , fetus , genetics , pregnancy , leucine , biology , genotype , amino acid , gene
The ratio of Gγ to Aγ chains was studied in 13 normal healthy newborns and in eight neonates with hydrops fetalis due to homozygous α‐thalassemia. The findings in the normal healthy newborns agreed with those of earlier reports. In homozygous α‐thalassemia the Gγ and Aγ ratio appeared generally lower than in healthy control newborns, but one of the hydrops fetalis cases had a very high Gγ value. In all 13 normal healthy newborns, in 8 patients with homozygous α‐thalassemia, and in 4 patients with homozygous β‐thalassemia, Tγ chains with threonine at position 75 were detected in addition to Iγ chains with isoleucine at position 75. In homozygous α‐thalassemia, the Tγ‐to‐Iγ ratio seemed lower and in homozygous β‐thalassemia higher than in normal newborns.