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Control of Hemoglobin Synthesis in Fetal Erythroid Cells by L‐Thyroxine
Author(s) -
Fuhr J. E.,
Dunn C. D. R.
Publication year - 1978
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830050213
Subject(s) - fetus , gestation , medicine , globin , endocrinology , hormone , fetal hemoglobin , hemoglobin , thyroid , protein biosynthesis , biology , chemistry , pregnancy , microbiology and biotechnology , genetics
Fetal mouse liver cells were incubated in the presence of L‐thyroxine. Globin synthesis by cells from the 13th to 15th days of gestation was stimulated by the presence of the hormone. Although protein synthesis by cells from the 17th day of gestation was stimulated, the protein was not identified as globin. A tentative conclusion was drawn that fetal erythroid tissue may be preferentially stimulated by thyroid hormone.