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Association of 5q− and refractory anemia
Author(s) -
Kaffe Sara,
Hsu Lillian Y. F.,
Hoffman Ronald,
Hirschhorn Kurt
Publication year - 1978
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830040309
Subject(s) - refractory anemia , refractory (planetary science) , anemia , medicine , bone marrow , myelodysplastic syndromes , leukemia , biology , astrobiology
Abstract The association of refractory anemia with partial deletion of the long arm of one No. 5 chromosome (5q−) has been reported in six patients within the last two years. We wish to report an additional patient with refractory anemia and an acquired chromosomal deletion, del(5)(q15), in a direct bone‐marrow preparation. The specificity of this deletion for refractory anemia is discussed. It remains to be seen whether patients with refractory anemia and 5q− tend to develop acute leukemia, as has been recently suggested.