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Penicillin‐induced immunohemolytic anemia associated with circulating immune complexes
Author(s) -
Funicella T.,
Weinger R. S.,
Moake J. L.,
Spruell M.,
Rossen R. D.
Publication year - 1977
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830030302
Subject(s) - penicillin , sensitization , immune system , immunology , complement system , anemia , complement (music) , medicine , hemolysis , hemolytic anemia , alternative complement pathway , red blood cell , immune complex , antibody , microbiology and biotechnology , chemistry , antibiotics , biology , biochemistry , complementation , gene , phenotype
Eleven days after administration of multiple penicillin analogs, a 55‐year‐old female developed a Coombs‐positive hemolytic anemia. The patient's erythrocytes were coated with IgG, complement components (C4/C3) and her serum contained elevated 125 I‐Clq binding activity (a measure of the presence of immune complexes). Her serum, in the presence of fresh complement and penicillin, induced complement sensitization of normal erythrocytes. Immune complex‐mediated complement activation and the haptene type of erythrocyte sensitization accounted for accelerated red blood cell destruction in this patient.