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Amphotericin inhibition of hematopoiesis in vitro
Author(s) -
Koeffler H. Phillip,
Golde David W.
Publication year - 1977
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830030107
Subject(s) - haematopoiesis , amphotericin b , in vitro , granulocyte , myeloid , bone marrow , progenitor cell , pharmacology , monocyte , biology , immunology , chemistry , stem cell , microbiology and biotechnology , biochemistry , antifungal
The effect of amphotericin B on human and murine hematopoiesis was studied in vitro using assays for erythroid and myeloid colony‐forming cells. Amphotericin consistently inhibited colony formation by erythroid and granulocyte‐monocyte progenitor cells. Clear effects were observable at amphotericin concentrations of 1.0 μg/ml, and concentrations of 2.0 μg/ml caused approximately 50‐60% inhibition of cloning of both murine and normal human bone marrow. These data suggest that amphotericin, in concentrations achieved in therapy, can impair hematopoiesis by a direct effect on precursor cells.